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Joint Disease and Osteoarthritis (OA)

We approach the pathophysiology and treatment of orthopedic disease from a 'One Health' perspective, studying joint disease in horses, dogs, and humans with the goal of benefiting both veterinary and human patients alike.  Current efforts focus on evaluating the horse as a translational model for human intra-articular fracture and the dog as a translational model for human anterior cruciate ligament (ACL) injury with the goal of identifying conserved and robust biomarkers and therapeutic targets for OA.



Noordwijk KJ, Qin R, Diaz-Rubio ME, Zhang S, Su J, Mahal LK, Reesink HL. Metabolism and global protein glycosylation are differentially expressed in healthy and osteoarthritic equine carpal synovial fluid. Equine Vet J. 2022 Mar;54(2):323-333. doi: 10.1111/evj.13440. Epub 2021 Mar 18. PMID: 33587757. PMCID: PMC8364562.



Fasanello DC, Su J, Deng S, Yin R, Colville MJ, Berenson J, Kelly C, Freer H, Rollins A, Wagner B, Rivas F, Hall AR, Paszek MJ, Reesink HL. Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation. Arthritis Res. Ther. 2021 Aug 20;23(1):218. doi: 10.1186/s13075-021-02588-7. PMID: 34416923. PMCID: PMC8377964.


Watkins A, Fasanello D, Stefanovski D, Schurer S, Caracappa K, D’Agostino A, Costello E, Freer H, Rollins A, Read C, Su J, Colville M, Paszek M, Wagner B, Reesink HL. Investigation of synovial fluid lubricants and inflammatory cytokines in the horse: a comparison of recombinant equine interleukin 1𝛃-induced synovitis and joint lavage models. BMC Vet. Res. 2021 May 12;17(1)189. doi: 10.1186/s12917-021-02873-2. PMID: 33980227.



Wang Y, Gludish DW, Hayashi K, Todhunter RJ, Krotscheck U, Johnson PJ, Cummings BP, Su J, Reesink HL.  Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture.  Sci. Rep. 2020 Oct 7;10(1)16725. doi: 10.1038/s41598-020-73270-2. PMID: 33028842.


Watkins AR, Reesink HL.  Lubricin in experimental and naturally occurring osteoarthritis: a systematic review.  Osteoarthr. Cartilg. 2020 Oct;28(10):1303-1315. doi: 10.1016/j.joca.2020.05.009. Epub 2020 June 3. PMID: 32504786.


Peal BT, Gagliardi R, Su J, Fortier LA, Delco ML, Nixon AJ, Reesink HL.  Synovial fluid lubricin and hyaluronan are altered in equine osteochondral fragmentation, cartilage impact injury and full-thickness cartilage defect models. J Orthop Res. 2020 Aug;38(8):1826-1835. doi: 10.1002/jor.24597. Epub 2020 Feb 9. PMID: 31965593.


Feeney E, Peal BT, Inglis JE, Nixon AJ, Bonassar LJ, Reesink HL.  Temporal changes in synovial fluid composition and elastoviscous lubrication in the equine carpal fracture model.  J Orthop Res. 2019 May;37(5):1071-1079. doi: 10.1002/jor.24281. Epub 2019 Mar 28. PMID: 30859611.


Reesink HL, Nixon AJ, Su J, Liu S, Sutton RM, Mann S, Watts AE, Peterson RP. Galectins-1 and -3 increase in equine post-traumatic osteoarthritis.  Front Vet Sci. 2018 Nov 20;5:288. doi: 10.3389/fvets.2018.00288. PubMed PMID: PMC6256174.


Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR.  Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor. Nat Commun. 2018 March 12;9(1):1037. doi: 10.1038/s41467-018-03439-x. PMID: 29531292.

Peal BT, Pittman EM, Fortier LA, Mohammed HO, Reesink HL.  Investigation of intra-articular silicone oil as an adjunctive therapy for the treatment of equine osteoarthritis: 27 cases (2002-2016).  EMS Vet Sci J. 2018 March 2;1(1):002.


Reesink HL, Sutton RM, Shurer CR, Peterson RP, Tan JS, Su J, Paszek MJ, Nixon AJ.  Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility.  Stem Cell Res Ther. 2017 Nov 2;8(1):243. doi: 10.1186/s13287-017-0691-2. PMID: 29096716.


Reesink HL, Watts AE, Jay GD, Mohammed HO, Nixon AJ.  Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis.  Osteoarthritis Cartilage. 2017 Jan; 25(1):128-137; doi: 10.1016/j.joca.2016.07.021. PMID: 27498214. NIHMSID: 862929.


Reesink HL, Bonnevie ED, Liu S, Shurer CR, Hollander MJ, Bonassar LJ, Nixon AJ.  Galectin-3 binds to lubricin and reinforces the lubricating boundary layer of articular cartilage. Sci Rep. 2016; May 9; 6:25463. doi:10.1038/srep25463. PMID: 27157803.

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