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Lubricin Therapy &
Biotechnology

Lubricin, also called proteoglycan 4 (PRG4), is a sugar-rich proteoglycan that enables low-friction cartilage lubrication and promotes joint health.  Current efforts focus on investigating the safety and efficacy of recombinant lubricin and lubricin-inspired therapeutics for osteoarthritis.

Publications

2023

Park S, Kuo JC, Reesink HL, Paszek MJ.  Recombinant mucin biotechnology and engineering.  Adv Drug Deliv Rev. 2023 Feb; 193:114618. doi: 10.1016/j.addr.2022.114618. Epub 2022 Nov 11. PMID: 36375719. PMCID: PMC10253230.​

2022

Wang Y, Wagner ES, Yu D, Chen KJ, Keel TJ, Pownder SL, Koff MF, Cheetham J, Samaroo KJ, Reesink HL. Assessment of osteoarthritis functional outcomes and intra-articular injection volume in the rat anterior cruciate ligament transection model. J Orthop Res. 2022 Sep;40(9):2004-2014. doi: 10.1002/jor.25245. Epub 2022 Jan 7. PMID: 34994469.

 

Hayashi K, Bourgeois A, Lopez D, Caserto B, Berthelsen E, Krotscheck U, Reesink HL, Putnam D. Intra-articular administration of a synthetic lubricin in canine stifles. Vet Comp Orthop Traumatol. 2022 Mar;35(2):90-95. doi: 10.1055/s-0041-1736189. Epub 2021 Oct 1. PMID: 34598303.

2020

Watkins AR, Reesink HL.  Lubricin in experimental and naturally occurring osteoarthritis: a systematic review.  Osteoarthr. Cartilg. 2020 Oct;28(10):1303-1315. doi: 10.1016/j.joca.2020.05.009. Epub 2020 June 3. PMID: 32504786.

2019

Zhou C, Reesink H, Putnam D.  Selective and tunable galectin binding of glycopolymers synthesized by a generalizable conjugation method.  Biomacromolecules. 2019 Oct 14;20(10):3704-3712. doi: 10.1021/acs.biomac.9b00759. Epub 2019 Sep 6. PMID: 31403772.

Shurer C, Wang Y, Feeney E, Head S, Zhang V, Su J, Stark M, Bonassar L, Reesink HL, Paszek M.  Stable recombinant production of codon-scrambled lubricin and mucin in human cells.  Biotech Bioengin. 2019 Jun;116(6):1292-1303. doi: 10.1002/bit.26940. Epub 2019 Mar 8. PMID: 30684357.

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